Postdoctoral Fellow

Dmitry A. Kondrashov Dept. of Biochemistry Faculty Supervisor: George N. Phillips, Jr. Email: dkon@biochem.wisc.edu 262- 3408

Large-scale motions of proteins present a rich fundamental problem with a large potential for application to understanding protein function. Many, if not most, proteins undergo dynamic changes in the course of performing their functions. My research involves building on existing coarse-grained models and rigorously testing computed protein dynamics against experimental measures of dynamics, such as diffuse scattering in X-ray crystallography, NMR spin relaxation, and deuterium-hydrogen exchange mass spectrometry. The goal is to capture protein dynamics on an intermediate length scale of two to three angstroms.

CV

CV 2005 ( pdf format)

Publications

Kondrashov, D.A., Roberts, S.A, Weichsel, A., and Montfort, W.R. “Protein functional cycle viewed at atomic resolution: conformational change and mobility in nitrophorin 4 as a function of pH and NO binding”, Biochemistry 43 pp 13637–13647 (2004)

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