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Predoctoral Trainee
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Eric L. Haseltine
Chemical and Biological Engineering Doctoral
Training Program
Dept. of Chemical and Biological Engineering
Faculty Supervisors: John Yin and James Rawlings
Email: haseltin@bevo.che.wisc.edu
265-2378
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Towards a Better Understanding of Cell-Cell Signaling
Induced by Viral Infection
Most chemical reaction models of viral infections focus exclusively on
either the intracellular level or the extracellular level. To more realistically
model these infections, we propose incorporating both levels of information
into the description. Previously, we demonstrated that cell population
balances present one way of performing this task (Haseltine, E. L., Rawlings,
J. B., and Yin, J., submitted). Our results demonstrate that the cell
population balance provides an intuitive and flexible modeling framework
for incorporating all events occurring during viral infections. We are
extending this modeling technique to spatially resolving the propagation
of virus in a growing plaque. The studied virus/host system is vesicular
stomatitis virus propagating in hamster kidney epithelial (BHK-21) and
murine astrocytoma (DBT) cell lines. Duca et al. observe that the DBT
cells can develop an anti-viral state while the BHK cells remain susceptible
to infection (Duca et al., Biotech. Progr. 17: 1156, 2001; Lam, K., Duca,
A., and Yin, J., submitted). Lam et al. show that the spatial and temporal
development of the anti-viral state in DBT cell monolayers is mediated
by cytokines (Lam, K., Duca, A., and Yin, J., submitted). By modeling
this experimental system, we seek to better understand the exact role
that cytokines play in defending against viral infections, and how to
best control this defense mechanism.
CV
CV (.pdf
format)
Publications
Haseltine, E. L., J. B. Rawlings and J. Yin (submitted). "Dynamics
of viral infections: Incorporating both the intracellular and extracellular
levels."
Search for publications by Eric Haseltine (Pub
Med)
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